Common "Depakote" queries answered by top doctors | iCliniq


Depakote, also called sodium valproate, is a mood stabilizer medication that works in the brain. It is used for manic depression (mania associated with bipolar disorder), epilepsy (seizures), and migraine headaches. It causes drowsiness, abdominal pain, nausea, diarrhea, low platelet count, vomiting, tremors, hair loss, and tiredness.

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After taking Divalproex sodium for the last 2 years, I had no symptoms until a year ago. Should I continue the medication?

Query: Hello doctor, I have been taking 250 mg of Depakote daily for the past year to manage my bipolar symptoms. Initially, two years back, I started with a daily dose of 500 mg. Since then, I have not experienced any mood swings or depressive symptoms throughout the past year. I have a history of trauma ...  Read Full »

Dr. Anantha Kalyan D

Answer: Hello, Welcome to I read your query and understand your concern. I have taken note of your mention that you have been on Depakote (Divalproex sodium) 250mg for a year, along with your past history of depression and previous use of Risperidone 1mg. I would like to understand whether y...  Read Full »

I read Depakote and Paroxetine can cause Parkinson's. How to stop them without withdrawal symptoms?

Query: Hello doctor, I am suffering from OCD and doctor prescribed Depakote XR 500 mg and Paroxetine CR 25 mg, which I am taking for last eight years. I read that these medicines can cause drug-induced Parkinson's. Please advise how to stop taking these medicines without withdrawal symptoms.  Read Full »

Dr. Vishal Anilkumar Gandhi

Answer: Hello, Welcome to I do not think that those medications can induce Parkinson's. Antipsychotic drugs are more common to induce extrapyramidal symptoms like Parkinson's. Still, if you want to stop it, then you need to taper off over months gradually. It may lead to worsening your OCD.  Read Full »

Do I need liver supplements while taking Depakote?

Query: Hello doctor, Are there any liver supplements that I can take while on Risperdal and Depakote?  Read Full »

Dr. Surabhi

Answer: Hi, Welcome to The side effects of Depakote (Sodium valproate) on the liver are quite common and well known. It does cause an increase in liver enzymes level and symptoms like weakness, lethargy, jaundice (yellowing of skin and sclera), loss of appetite - all due to its effect on the ...  Read Full »

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