Bowenoid Papulosis (Polycentric Pigmented Bowen's Disease,Reversible Vulval Atypia, Genital Multicenter Bowen's Disease, Bowenoid Papulosis)

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Bowenoid Papulosis
Body Parts: Reproductive Site
Medical Subjects: Skin
Overview

What Is Bowenoid Papulosis

What disease is bowenoid papulosis?

The pathological change of this disease is a genital lesion similar to squamous cell carcinoma in situ. It was first proposed by Lloyd in 1970 and has continuously changed its name ever since. It is now recognized as "Bowenoid papulosis", a Class III intraepidermal neoplasm.

It is mainly characterized by benign, multiple, pigmented maculopapules at the genital sites, which are infectious, with carcinomatous changes in situ in histopathology, considered as a transitional state between genital warts and squamous cell carcinoma in situ, which are generally benign and can resolve on their own, rarely transforming into squamous cell carcinoma.

Cause

What Is The Cause Of Bowenoid Papulosis

What is the cause of bowenoid papulosis?

The study found that there were virus particle formation in the epidermal keratinocytes of the skin lesion and HPV (human papillomavirus) structural antigen in the lesion tissue section. In addition, it was found that the disease was closely related to HPV-16 type, and it was considered that the disease was a genital precancerous state caused by high-risk HPV infection, which could be transmitted through sexual contact, mother-to-child transmission, indirect transmission, etc.

What are the common populations of bowenoid papulosis?

It occurs mainly in young people aged between 21 and 30 years old in the sexually active period. The disease can occur in both men and women, but is mainly in men.

Symptom

What Are The Symptoms Of Bowenoid Papulosis

What is the main manifestation of bowenoid papulosis?

The skin lesions were single or multiple papules, flesh-colored, reddish-brown or black, with different sizes and a diameter of 2–10 mm, and they were round, elliptical or irregular in shape with a clear boundary. The surface of the papules could be bright and presented the appearance of velvet, or the mild keratosis presented the warty shape. The skin lesions were scattered in a stepwise or clustered arrangement and presented the shape of line or ring, or even they could be fused into plaques.

It usually occurs in the groin, external genitalia, and perianal skin mucosa, of which, for males, it occurs in the penis and glans penis, and for females, it occurs in the labia minora and perianal region. Generally no symptoms, some patients have itching or burning sensation.

The course of the disease is chronic, and lesions in a few patients spontaneously resolve, but they may recur with the possibility of conversion to invasive carcinoma.

Detect

How To Check For Bowenoid Papulosis

How is bowenoid papulosis diagnosed?

On the basis of an epidemiological history such as sexual contact, the manifestations of the rash lend themselves to a diagnosis that is supplemented, if necessary, by histopathological examinations.

It is a benign pleomorphic change that is often misdiagnosed, but it has special histological features similar to squamous cell carcinoma in situ that can be distinguished clinically through its benign features.

The difference between this disease and Bowen's disease is that Bowen's disease mostly occurs in the elderly. The skin lesions often show as single large plaques on the glans penis, and the plaques gradually centrifuge and grow with infiltration. The disease is mainly found in young people in the sexually active period. The skin lesions are multiple and there is pigmentation.

Prevention

How To Prevent Bowenoid Papulosis

How to prevent bowenoid papulosis?

The disease is highly infectious and patients and their partners should have regular physical examinations and follow-ups.

Paying attention to personal hygiene, avoiding unsafe sex, reducing the chance of illness and vaccinating HPV vaccine can play a certain role in prevention.

Treatment

How To Treat Bowenoid Papulosis

How does bowenoid papulosis treat?

Surgical resection is the best, but it is not suitable for large-scale resection.

Electrocautery, freezing, carbon dioxide laser, and corrosive can be used to remove small-scale damage. 5-Fu cream can also be used for topical application. Laser treatment is also effective and less prone to scarring.

Other effective therapeutic methods include oral administration of vitamin A acid, external application of cidofovir, external application of 5% imiquimod, and photodynamic therapy.

Life

What Should Patients With Bowenoid Papulosis Pay Attention To In Life

What is the prognosis of bowenoid papulosis?

Skin lesions are mostly benign processes that can spontaneously resolve. Invasive cancer progression is rare, but there is the possibility of recurrence.

It may eventually lead to pigmentation, and scar may appear after surgical treatment. Some patients may have complications such as ulcer, hemorrhage and canceration.

How to prevent bowenoid papulosis?

The disease is highly infectious and patients and their partners should have regular physical examinations and follow-ups.

Paying attention to personal hygiene, avoiding unsafe sex, reducing the chance of illness and vaccinating HPV vaccine can play a certain role in prevention.

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