Hyperglobulinemic Purpura

Hyperglobulinemic Purpura
Body Parts: Lower Limbs
Medical Subjects: Skin Blood

What Is Hypergammaglobulinemic Purpura

What is purpura of high globulin hematic disease?

Hypergammaglobulinemic purpura is a rare disease, and the pathogenesis is currently unclear, but it is related to the abundant production of immunoglobulins.

Hypergammaglobulinemic purpura is characterized by recurrent skin ecchymosis and petechia, with hyperpigmentation but a high number of platelets.

Hypergammaglobulinemic purpura occurs frequently in women and is generally a chronic benign disease that does not threaten life. However, some hypergammaglobulinemic purpura is secondary to multiple myeloma, Sjogren's syndrome and other more difficult-to-cure diseases.


What Is The Aetiology Of Sex Purpura Of High Globulin Blood Disease

Why can purpura of hypergammaglobulinemia happen?

The specific pathogenesis is currently unknown. It is possible that the marked increase in globulin in plasma caused by various reasons leads to an increase in vascular fragility, and thus skin purpura occurs.

What reason is purpura of high globulin blood disease caused?

Acute and chronic infection, malignant tumor, autoimmune disease, chronic liver disease, plasma cell disease, etc., may lead to hypergammaglobulinemic purpura, and no definite etiology can be found for some hypergammaglobulinemic purpura.

In the presence of the above diseases, alcohol consumption, wearing tights, exposure to overheating, standing or walking for a long time, and sunlight can all induce the onset of purpura.

Can purpura of hypergammaglobulinemia infect?



What Symptom Does Sex Purpura Of High Globulin Blood Have

What performance does sex purpura of high globulin blood have?

The onset was insidious, with the appearance of a small red macula on the skin first, followed by the rapid formation of petechia which fused into ecchymosis, known as "purpura".

Purpura mainly occurs in the skin of lower limbs, most serious in the front of lower limbs and dorsum of feet, with bilateral symmetry, and occasional mild pruritus, stabbing pain or burning sensation. Purpura often recurs and disappears with brown spots, called "pigmentation".

Some patients may have such symptoms as fever, night sweats (a lot of sweats during night sleep), inflammation and swelling of systemic lymph nodes, fatigue, weight loss, and joint and muscle pain.


How To Check For Hyperglobulinemic Purpura

What check should hypergammaglobulinemic purpura do?

Routine blood test, liver function, coagulation function, erythrocyte sedimentation rate, rheumatoid factor, serum protein electrophoresis, and antibodies against Ro/SSA antigen are required.

Patients with hypergammaglobulinemic purpura may present with:

  • Leukopenia, mild anemia;

  • Serum globulin elevated;

  • Erythrocyte sedimentation rate increases;

  • Rheumatoid factor positive;

  • Polyclonal increase of gamma globulin;

  • Positive anti-Ro/SSA, which suggests that the patient may develop Sjogren's syndrome or systemic lupus erythematosus.

What is the performance of skin biopsy of patients with hypergammaglobulinemic purpura?

Perivascular inflammation of lymphocytes with red blood cell exudation, or leukocytoclastic vasculitis.

Which diseases are easily confused with hypergammaglobulinemic purpura?

  • Macroglobulinemic purpura: Laboratory tests showed an increase in macroglobulins, a decrease in coagulation factors, an extension of bleeding time, and positive urine albumin. It can be accompanied by Reynaud's syndrome and urticaria, etc.

  • Cold globulin hematic purpura: cold can appear purpura, blood cold globulin positive, erythrocyte sedimentation rate accelerated at room temperature. It can be accompanied by cold urticaria, Raynaud's syndrome, and reticulocytosis.


How To Prevent Hypergammaglobulinemic Purpura

Can hypergammaglobulinemic purpura be prevented?

As the pathogenesis is unknown, there is currently no method of prevention.


How To Treat Hypergammaglobulinemic Purpura

Which department should hypergammaglobulinemic purpura see?

Hematology department.

Does hypergammaglobulinemic purpura need hospitalization?

HGP itself can be treated by oral medication without hospitalization, but severe primary diseases (such as severe infection and malignant tumor) require hospitalization.

How does sex purpura of hypergammaglobulinemia treat?

Treatment may be given with appropriate amounts of glucocorticoids, antimalarial drugs, colchicine, indomethacin, azathioprine, chlorambucil, mycophenolate mofetil, and plasma exchange if necessary. Vitamin E and vitamin C can be combined for adjuvant treatment.

What serious consequence can hypergammaglobulinemic purpura have if do not treat?

Hypergammaglobulinemic purpura can occur alone or secondary to other diseases, which may indicate a potentially serious disease at this time. If attention is not paid to it and it is treated, it may cause misdiagnosis or missed diagnosis, and delay the treatment opportunity.

Can high globulin hematic disease sex purpura cure?

Not necessarily, it depends on what the primary disease is. Hypergammaglobulinemic purpura can be secondary to a variety of diseases, and different diseases have different therapeutic effects.

Is purpura of hypergammaglobulinemia easy relapsed?

Hypergammaglobulinemic purpura can recur and pigmentation remains on the skin surface.


What Should The Patient Of Purpura Of Hypergammaglobulinemia Notice In Life

What should the patient of purpura of hypergammaglobulinemia notice in life?

Hypergammaglobulinemic purpura is prone to repeated attacks, so we should pay attention to avoid inducing attack factors in life:

  • Abstaining from alcohol;

  • Dress loosely and do not wear tights;

  • Go out to play umbrella, pay attention to cover the skin, avoid direct sunlight, also don't exposed to overheating environment;

  • Avoid standing or walking for long periods of time.

What should the patient of purpura of hypergammaglobulinemia notice on diet?

Dietary precautions depend primarily on the primary disease that causes hypergammaglobulinemic purpura, and you are advised to consult your own attending physician.

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