Medical Subjects: Skin

What Is A Syringoma

What is a syringoma?

Syringoma is a benign eccrine ductal tumor.

Most of them were one or more small miliary papules with a diameter of several millimeters to 1 cm, red, tan, pale yellow or the same color as the skin, and the surface was lustrous.

It can occur at any age, and the number of female patients is at least 2 times that of male patients; There are more adolescent and middle-aged women, and adolescence is aggravating. During pregnancy, premenstrual period and when female hormones are used, rash of syringoma will increase swelling in some cases.

The disease is currently considered to be closely related to endocrinology. Some patients have a family history.


What Is The Etiology Of Syringoma

What is eccrine duct?

Appendages of the skin include nail, hair, sweat gland and sebaceous gland. Among them, sweat glands are divided into eccrine sweat glands and apocrine sweat glands (once called "sweat glands"). Sweat gland consists of secretion part and duct part. The secretion part is in the deep layer of skin, while the duct part is in the shallow layer and opens at the hair follicle. Therefore, the sweat gland duct is the sweat gland duct of the sweat gland.

Why is syringoma eccrine gland conduit tumor?

This question is very professional, understanding need to have the necessary knowledge. On the whole, the harm is little or no, don't worry about it.

Pathological sections of syringoma showed that most of the basophilic epithelial cells in the upper part of the dermis gathered into small masses, which could be round or oval in shape, with the maximum diameter not exceeding the length of 10 cells. Some cell masses may be in the shape of cords, and most cell cords have a lumen-like space in the center, presenting as a poorly developed sweat gland duct. The catheter was filled with a grayish blue denatured material or eosinophilic amorphous material that was positive for amylase-resistant PAS.

The most characteristic pathological manifestation is that one end is in the shape of a catheter, and the other end is a solid cell cord, the whole shape is like a tadpole or a comma. Many studies have shown that these agglomerated epithelial cells contain succinate dehydrogenase, phosphatase, and leucine aminotransferase, suggesting that they originate from the eccrine glands.

What is the etiology of syringoma?

The etiology of syringoma has not been clearly studied at present. According to the fact that the number of female patients with this disease is at least two times that of male patients and it usually aggravates during adolescence, the rash of syringoma will be enlarged and swollen during premenstrual period, pregnancy and when female hormones are used. Hence, it is speculated that syringoma is related to endocrine, that is, hormones in the human body.

Can syringoma infect?

Syringoma is not an infectious disease, it's not contagious.

Does syringoma can heredity?

Recent studies have shown that the occurrence of syringoma has a certain relationship with heredity, but the specific way is still unclear.


What Symptom Does Syringoma Have

What is the feeling of syringoma?

Most patients with syringoma have no pain or itching and have no special feelings. Some patient have a burning or itching sensation when expose to heat, perspiration, or that sun. Patients with syringoma growing in the vulva often have a itchy sensation.

Where do syringoma grow?

Most of them grow on the lower eyelid, face and neck, axillary and vulva, etc. Syringoma is divided into 3 types:

  • Eyelid type: is the most common type. Usually grows in the lower eyelid, also has the upper eyelid to appear. Mostly in the development period and after;

  • Rash type: It is more common for male teenagers. The rash usually appears in batches in front of the chest, abdomen and the inner surface of upper arm.

  • Localized type: It grows locally at the vulva and clitoris, called "genital syringoma"; it grows locally at the back of the finger, called "limb syringoma".

In addition to the above classification, syringoma may grow in other sites. They are mostly symmetrically distributed and rarely unilateral or linear.

What are the main manifestations of syringoma?

Syringoma presented as one solitary scattered or densely distributed multiple small papules, usually several millimeters in diameter and even 1 cm; in individual ones; The papules were red, tan, pale yellow or the same color as the skin, with a waxy sheen on the surface, most resembling millet grains.

What harm can syringoma have to human body?

Syringoma is a benign eccrine ductal tumor located in the superficial layer of the dermis with pathological features of multiple cystic dilated eccrine ducts and basophilic cords without cellular atypia and malignant proliferation of tumor cells. The clinical manifestations were small papules, and the patients generally had no special feelings.

Therefore, the disease has no obvious harm to the human body except that it may affect the beautiful appearance or produce a little pruritus.

Can syringoma become cancer?

Syringoma is a benign eccrine ductal tumor. The pathological tissue shows that there are many basophilic epithelial cells in the upper dermis that aggregate into small masses. The cell masses may be round or oval, with the maximum diameter not exceeding the length of 10 cells.

Some cell masses can be in the shape of cords; in most cell cords, there is a lumen-like space in the center, presenting as a poorly developed sweat gland duct, that is, one end is in the shape of a duct, and the other end is a solid cell cord, with the whole shape like a tadpole or a comma.

Studies have shown that these agglomerated epithelial cells contain succinate dehydrogenase, phosphatase, and leucine aminotransferase, suggesting that they originate from the eccrine glands.

There were no cellular atypia in the histopathology of syringoma and there were no hypermalignant neoplastic cells. Usually syringoma does not become cancer.


How To Check For Syringoma

Do you need to do an examination to confirm the diagnosis of syringoma?

Syringoma can be diagnosed with typical clinical manifestations according to the characteristics of common sites (such as eyelid) and common population, and generally does not need special examination. Sometimes skin biopsy can be performed, and the diagnosis can be confirmed more intuitively under the pathology.

What is the difference between syringoma and xanthelasma?

Xanthelasma of eyelid, also called "xanthelasma of eyelid", is one of the most common xanthelasma. It is more common in middle-aged women.

They present as symmetrically distributed orange papules or plaques around the upper eyelid or inner canthus, or may grow on the periphery or lateral side of the eye. Xanthelasma exists for a long time and develops progressively over time and can also fuse with each other.

Most patients with this disease have normal blood lipids; however, this disease is often associated with other types of xanthoma (e.g., Tendon's tumor, nodular xanthoma, etc.).

What is the difference between syringoma and verruca plana?

Verruca plana is a chronic benign disease caused by human papillomavirus (HPV) infection. Since the disease mainly involves teenagers, it is also called "young verruca plana".

Most of the cases were sudden onset, and flat papules the size of rice grains to mung beans appeared on the face, back of hand or forearm, with a smooth surface and a light brown or normal skin color. The number of papules was relatively large, and most of them were distributed densely, and sometimes the papules were distributed in strips along the scratches.

Patients generally do not have special feelings and sometimes feel slight itching. Some can disappear by themselves after many years, and some can survive for many years. No scar is left after cure.

How to differentiate between syringoma and microcystic adnexal carcinoma?

Microcystic adnexal carcinoma, also known as "sclerosing sweat duct carcinoma" and "malignant sweat duct tumor", is an aggressive malignant adnexal tumor.

The incidence of that disease is low. It usually occurs in the head, especially the nose and lips, around the orbit, but can also occur in the axillary and breast skin. "it is a hard plaque of yellow, red, or skin color, with a prominent fovea in the center and an indistinct border that sometimes leads to ulceration.".

Patients generally do not feel pain or itching, but when the tumor invades the nerves, they may have abnormal feelings such as pain and burning sensation.

Early surgery is generally needed for complete resection, otherwise recurrence is easy. The pathological presentation of the disease is well distinguished from a syringoma: mild atypia of the nucleus, the presence of angular cysts, and mitosis.


How To Prevent Syringoma

Can syringoma prevent?

Since the pathogenesis of syringoma is still unclear, no effective preventive measures have been taken so far.


How To Treat Syringoma

Does syringoma must treat?

Since syringoma is a benign tumor that has no significant effect on the human body, it generally does not require treatment.

What are the common treatment methods of syringoma?

At present, electric drying, freezing, laser and high-frequency electrocautery are adopted for the treatment of syringoma.

Can you leave sequela after treatment of syringoma?

Since the skin of the eyelid part is relatively loose, and two-thirds of the dermis layer is involved by the syringoma tumor, scars are easily left after treatments such as freezing, electrolysis, and laser treatment.

There are several ways of laser treatment of syringoma.

At present, the laser methods for the treatment of syringoma in scientific, clinical and practical applications are as follows:

  • Q-switch 1064nm laser;

  • Ultra-pulse CO2 laser:

  • Erbium laser;

  • Nd: yag 532 nm laser;

  • Lattice laser.

What is the contraindication of laser treatment of syringoma?

  • Patients who are themselves photosensitive skin, patients who are allergic to ultraviolet light, or who have recently taken photosensitive drugs (such as isoretinoic acid)

  • Patients with scar constitution;

  • Menstrual period, pregnancy and lactation female patients;

  • Patients with coagulation disorders or taking anticoagulants;

  • Patients with symptoms of infection at the site requiring laser treatment;

  • Patients taking immunosuppressants and other neoplastic conditions.

What are the possible adverse reactions of physical therapy for syringoma?

  • Pain: Some patients may have slight pain after refrigeration and laser treatment.

  • Edema: Sometimes mild edema occurs at the treatment site after laser treatment, and it generally disappears after 4 weeks.

  • Cicatrix hyperplasia: Because syringoma involves dermal layer, it is easy to leave cicatrix.

  • Redness of the skin: It may be caused by injury to normal capillaries during cryosurgery or electrolysis, or by infection.

  • Infection: Physical therapy may cause infection. Once discovered, it should be timely diagnosed and treated.

  • Pigmentation: The incidence is high and usually occurs about one month after surgery.

Can syringoma attack repeatedly?

Some patients may have recurrence after the treatment of syringoma. Due to large differences in local statistical data and limited sample size, the exact recurrence rate cannot be known at present.


What Should The Patient Of Syringoma Notice In Life

What should the patient of syringoma notice in life

As the laser is invasive treatment, the local wound surface will be caused after the treatment of syringoma. The scab on the wound surface needs a certain period of time; the wound surface must naturally fall off. Before the scab skin falls off, the wound surface cannot touch water. Therefore, the user should avoid eating spicy and other excitant foods, such as chili, raw scallion, ginger and garlic, and preferably avoid drinking alcohol. Go out should pay attention to prevent bask in, avoid the pigmented spot after leaving inflammation.

Can syringoma still use cosmetic after growing in the face?

Sure. Syringoma is a tumor located in the upper layer of dermis, with no crevasse on the skin surface, and does not affect the use of skin care products, cosmetics, etc.

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